Upcoming Webinars
Join us at an upcoming webinar.
On-Demand Webinars
View our on-demand webinars.
MIDD Webinar Series
MIDD Webinar Series
ACoP2024 Recorded Sessions
View the recorded sessions from ACoP 2024
Upcoming Live Webinars
Join us at one of our upcoming webinars.
-
Contains 1 Component(s) Includes a Live Web Event on 04/08/2026 at 12:00 PM (EDT)
This webinar will focus on the PKPD models developed and used end-to-end to design and execute a Phase 1 study for a first brain-penetrant PROTAC ARV-102. Core PKPD models were developed using nonclinical data and included allometrically scaled PK parameters and animal-derived PD parameters for target engagement. Model simulations were used to select a dose range for the first in human study and the PKPD models were updated to refine the dose response. The iterative modeling-experimentation resulted in a successful Phase 1 study and illuminated important translational relationship of PROTAC PKPD between animals and humans.
-
You must log in to register
- Non-member - $50
- Member - Free!
- More Information
-
You must log in to register
| Access Date | Quiz Result | Score | Actions |
|---|